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  3. Creatine Monohydrate: The Most Researched Supplement

Creatine Monohydrate: The Most Researched Supplement

ali@avitazen.com
Nov 16, 2025
8 min read

Discover why creatine monohydrate is considered the most effective and safe supplement for strength, power, and muscle growth.

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muscle building
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Creatine monohydrate is arguably the most well-researched and effective supplement in sports nutrition. With hundreds of studies supporting its benefits, it's a must-have for anyone serious about strength and performance.

How Creatine Works

Creatine increases your muscles' phosphocreatine stores, which helps produce more ATP (energy) during high-intensity exercise. This leads to:

- Increased strength and power output - Enhanced muscle growth - Improved high-intensity exercise performance - Faster recovery between sets

The Science-Backed Benefits

Strength Gains: Studies show 5-15% increases in strength when combined with resistance training.

Muscle Growth: Helps build muscle directly through increased training volume and indirectly through cell volumization.

Cognitive Benefits: Emerging research suggests benefits for brain function, especially during sleep deprivation or mental fatigue.

Safe for Long-Term Use: Over 20 years of research shows creatine is safe for healthy individuals.

Loading Phase vs. Standard Dosing

Loading Phase (Optional): - 20g daily for 5-7 days (4 doses of 5g) - Saturates muscles quickly - Results in 3-5 days

Standard Dosing (Recommended): - 5g daily consistently - Achieves same saturation in 3-4 weeks - No digestive issues - More cost-effective

When to Take Creatine

Recent research suggests timing doesn't matter significantly. Take your 5g whenever it's convenient, though post-workout with carbs may offer slight advantages.

Creatine Myths Debunked

Myth: Creatine causes kidney damage **Reality

Myth: You need to cycle creatine **Reality

Myth: Creatine causes dehydration **Reality

Myth: Other forms are better than monohydrate **Reality

Who Should Take Creatine?

Nearly everyone engaged in resistance training or high-intensity sports can benefit. Vegetarians and vegans may see even greater benefits as they have lower baseline creatine levels.

Choosing Quality Creatine

Look for: - Micronized creatine monohydrate - Third-party tested - No added ingredients (pure creatine) - Creapure® certified (optional but ensures quality)